PPPTH: Phase II Randomized Trial of Topical Papaverine to Prevent Postoperative Hypoparathyroidism After Total Thyroidectomy
Sponsor: Azienda Provinciale Per I Servizi Sanitari
Phase: 2
Disease: Postoperative hypoparathyroidism, Postoperative hypocalcemia
EU trial number: 2026-527270-37-00
Population: Adults aged 18–79 undergoing total thyroidectomy for benign or malignant thyroid conditions, with normal preoperative calcium, parathyroid hormone, magnesium and vitamin D and ASA status ≤2, excluding previous neck surgery, pregnancy, severe relevant comorbidities and contraindications to papaverine. The study investigates prevention of transient and persistent postoperative parathyroid dysfunction rather than treatment of underlying thyroid disease.
Register Investigator Interest
Interested in offering this trial to suitable patients?